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Harnessing the power of macrophages

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Neutral Clodronate Liposomes

Anionic Clodronate Liposomes

Fluorescent Liposomes
Clodronate Liposomes-N(Neutral)

Clodronate Liposomes-N(Neutral)
Control for Clophosome®-N(Neutral)

Control for Clophosome®-N(Neutral)
Clophosome®-N & Control Liposomes

Clophosome®-N & Control Liposomes
Clodronate Liposomes-A(Anionic)

Clodronate Liposomes-A(Anionic)
Control for Clophosome®-A(Anionic)

Control for Clophosome®-A(Anionic)
Clophosome®-A & Control Liposomes

Clophosome®-A & Control Liposomes
Fluorescent DiI Liposomes (Neutral)

Fluorescent DiI Liposomes (Neutral)
Fluorescent DiI Liposomes (Anionic)

Fluorescent DiI Liposomes (Anionic)
Fluorescent DiO Liposomes (Neutral)

Fluorescent DiO Liposomes (Neutral)
Fluorescent DiO Liposomes (Anionic)

Fluorescent DiO Liposomes (Anionic)
Fluorescent DiD Liposomes (Neutral)

Fluorescent DiD Liposomes (Neutral)
Fluorescent DiD Liposomes (Anionic)

Fluorescent DiD Liposomes (Anionic)
Fluorescent DiA Liposomes (Neutral)

Fluorescent DiA Liposomes (Neutral)
Fluorescent DiA Liposomes (Anionic)

Fluorescent DiA Liposomes (Anionic)
Fluorescent DiR Liposomes (Neutral)

Fluorescent DiR Liposomes (Neutral)
Fluorescent DiR Liposomes (Anionic)

Fluorescent DiR Liposomes (Anionic)
响应式图片示例
Mechanisms of macrophage depletion
Routes of liposome administration
Advances in macrophage research
Mechanisms of macrophage depletion

Mechanisms of macrophage depletion

Clodronate liposomes are composed of clodronate molecules encapsulated in neutral/anionic liposomes, which are able to achieve the macrophage depletion after a single intravenous or intraperitoneal administration. Clodronate is a type of non-toxic bisphosphonate, and freely solved clodronate will not cross liposomal or cellular phospholipid membranes. After injection, bilayers of the liposomes can be ingested and digested by the lysosomal phospholipases in the macrophage to release clodronate and accumulate intracellularly. Once a certain intracellular concentration is reached, clodronate can induce the irreversible damage and apoptosis of macrophage. Clodronate liposomes represent a pivotal advancement in the field of cellular biology, particularly in the study of the immune system.

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Clodronate

Clodronate, also known as clodronic acid, is a synthetic bisphosphonate that plays a significant role in inhib…

Liposomes

Liposomes are closed spherical structures formed by self-assembly of lipids into bilayers (monolayers) and/or …

Clodronate Liposomes

Clodronate liposomes are lipid-based nanoparticles that encapsulate clodronate, a bisphosphonate compound trad…
Routes of liposome administration

Routes of liposome administration

The choice of administration route plays a pivotal role in determining how liposomes behave in biological systems. Factors such as tissue penetration, macrophage uptake, release kinetics, and immune response are significantly impacted by how and where liposomes are introduced. Whether the goal is targeted depletion of specific cell populations, localized drug delivery, or systemic circulation, selecting the appropriate route is essential to achieving optimal experimental or therapeutic outcomes. Each administration route offers distinct advantages and limitations based on the biological target, therapeutic goals, and the nature of the encapsulated agent (e.g., clodronate, RNA, proteins). Some routes are ideal for localized depletion of macrophages, while others are preferred for systemic effects or mucosal immunity studies.

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Intravenous injection

Intravenous injection(IV), the most common method of dosing clodronate liposomes; about half of all clodronate…

Intraperitoneal injection

Intraperitoneal(IP) administration of liposomes employs a direct delivery technique where liposomes carrying t…

Intranasal instillation

Intranasal /Inhalation delivery is a method of administering medicine by inhaling it through the nose. As we a…
Advances in macrophage research

Advances in macrophage research

Macrophages are strategically distributed throughout the body. They are often described as "a double-edged sword" due to their complex roles. Macrophages can act as both protective and pathogenic cells, depending on their activation state and the context in which they are found. Macrophages are highly heterogeneous cells that can rapidly change their function in response to local microenvironmental signals. Macrophages exhibit complex and diverse functions in the body, including phagocytosis and clearance of cellular debris, antigen presentation, and immune response, regulation of inflammation and cytokine production, tissue remodeling and repair, and multi-level regulatory signaling pathways/crosstalk involved in homeostasis, tumor and physiology. Targeting macrophages has emerged as a promising therapeutic strategy in these contexts.

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Niche-specific dermal macrophage loss promotes skin capillary ageing

AbstractAll mammalian organs depend on resident macrophage populations to coordinate repair and facilitate tis…

Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death

Macrophages are strategically distributed throughout the body. They are often described as "a double-edge…

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours

Macrophages are strategically distributed throughout the body. They are often described as "a double-edge…