The transition from monocyte to tissue-resident macrophage requires DHPS
A cell-intrinsic, tissue-agnostic pathway that drives differentiation of monocyte-derived macrophages into RTM…
A cell-intrinsic, tissue-agnostic pathway that drives differentiation of monocyte-derived macrophages into RTM…
AbstractObesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obes…
The indispensable role of ARPC5-containing, but not ARPC5L-containing, Arp2/3 complexes in mononuclear phagocy…
macrophages are key for MR1 antigen presentation and MAIT cell immunity.…
Highlights•MiTEs are novel myeloid-targeted immunocytokine prodrugs for cancer immunotherapy•TREM2 antagonis…
PU.1 expression in microglia is regulated not only genetically but also epigenetically by the microenvironment…
AbstractAll mammalian organs depend on resident macrophage populations to coordinate repair and facilitate tis…
Efferocytosis-associated reprogramming of the islet macrophages and the subsequent influence on the adaptive i…
A targetable epigenetic node of myeloid progenitor dysregulation that sustains immunoregulatory mo-macs in the…
Highlights•Astrocyte processes reduce contact with synapses before synapse removal by microglia•Microglia-de…
Highlights•Erythroblast island (EBI) macrophages are recruited to the bone metastatic niche•EBI macrophages …
In addition to their role in host defense, macrophages contribute to the development and remodeling of tissues…
AbstractAs tissue resident macrophages of the central nervous system (CNS) parenchyma, microglia perform diver…
Macrophages sense deviation in intracellular pH as a mechanism to guide the control of inflammatory responses.…
Clodronate, also known as clodronic acid, is a synthetic bisphosphonate that plays a significant role in inhib…
Liposomes are closed spherical structures formed by self-assembly of lipids into bilayers (monolayers) and/or …
Clodronate liposomes are lipid-based nanoparticles that encapsulate clodronate, a bisphosphonate compound trad…
Trojan horse, huge hollow wooden horse constructed by the Greeks to gain entrance into Troy during the Trojan …
Intravenous injection(IV), the most common method of dosing clodronate liposomes; about half of all clodronate…
Healthy tissue may be damaged by the activity of immune cells working to eradicate infection. Hoagland et al. …
Intraperitoneal(IP) administration of liposomes employs a direct delivery technique where liposomes carrying t…
AbstractAs tissue resident macrophages of the central nervous system (CNS) parenchyma, microglia perform diver…
Intranasal /Inhalation delivery is a method of administering medicine by inhaling it through the nose. As we a…
Intratracheal injection(IT) is a medical technique for delivering a substance directly into the trachea, or wi…
Intrathecal/Intraventricular injection of clodronate liposomes is a specialized medical procedure that holds g…
Intradermal injection (i.d. or ID) of clodronate liposomes has been used for elucidating the immune mechanisms…
Subcutaneous administration(SC) is done by injecting drugs into the fatty tissues just beneath the skin, which…
Intramuscular injection (IM) is installing medications into the depth of specifically selected muscles. The bu…
Retro-orbital injection(RO) is an acceptable alternative to the tail vein injection route, with proper trainin…
Intratumoral delivery（ITM） of drug represents a compelling solution to directly address local barriers to tu…
