Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity

AbstractObesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obes…

Branched actin networks mediate macrophage-dependent host-microbiota homeostasis

The indispensable role of ARPC5-containing, but not ARPC5L-containing, Arp2/3 complexes in mononuclear phagocy…

Macrophage MR1 antigen presentation promotes MAIT cell immunity and lung microbiota modulation

macrophages are key for MR1 antigen presentation and MAIT cell immunity.…

Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy

Highlights•MiTEs are novel myeloid-targeted immunocytokine prodrugs for cancer immunotherapy•TREM2 antagonis…

Lymphoid gene expression supports neuroprotective microglia function

PU.1 expression in microglia is regulated not only genetically but also epigenetically by the microenvironment…