Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states

AbstractAgeing is accompanied by declining memory function, with extremely heterogeneous manifestation in the …

Early fibrotic niches establish tumour-permissive microenvironments

AbstractPathologic transformation represents a critical yet poorly defined window during which mutant epitheli…

Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity

INTRODUCTIONMacrophages in the tumor microenvironment exert antitumorigenic effects through phagocytosis and/o…

Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis

AbstractBody–brain communication has emerged as a key regulator of tissue homeostasis. Solid tumours are inne…

Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors

INTRODUCTIONIn vivo delivery systems (IDSs) are essential for enabling the clinical use of therapeutic agents …